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5-HT systems, acting through central 5-HT2 receptors, have been implicated in controlling mood, social behaviour, sleep patterns, depression, anxiety and negative symptoms in schizophrenia Leysen and Pauwels,1990. Down-regulation of 5-HT2 receptors also has been reported consistently during dementing processes and dementia Cross et al., 1986 Gross-Isseroff et al.,1990.
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