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Winstock A, Mitcheson L, Ramsey J, Marsden J. 
“Mephedrone: use, subjective effects and health risks”. 
Addiction. 2011 May 19.
Aims.  To assess the patterns of use, subjective effect profile and dependence liability of mephedrone, supported by corroborative urine toxicology. Design.  Cross sectional structured telephone interview.

SETTING:  UK based drug users associated with the dance music scene. Participants.  100 mephedrone users, recruited through their involvement with the dance music scene. Measurements.  Assessment of pattern of use, acute and after effects, effects, DSM dependence criteria and GMCS urinalysis. Findings  Mephedrone consumption results in typical stimulant-related subjective effects: euphoria, increased concentration, talkativeness, urge to move, empathy, jaw clenching, reduced appetite and insomnia. Thirty per cent of the sample potentially met criteria for DSM-IV dependence and there was evidence of a strong compulsion to use the drug (47% had used the drug for two or more consecutive days). Self-reported recent consumption of mephedrone was confirmed by toxicology analysis in all of the 14 participants who submitted a urine sample. Conclusion.  Mephedrone has a high abuse and health risk liability, with increased tolerance, impaired control and a compulsion to use, the predominant reported dependence symptoms.
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