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Gilsdorf RT, Nord FF.
“STUDIES ON THE CHEMISTRY OF HETEROCYCLICS. IX. REDUCTION OF THIENYL NITROOLEFINS WITH LITHIUM ALUMINUM HYDRIDE'”.
The Department of Organic Chemistry and Enzymology. 1950 Jan 16;? (193):807-11.
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Abstract
A new and direct synthesis of the pharmacologically active P-(2-thienyl)ethylamine (1, 2) and 8-(2-thienyl)isopropylamine (2, 3), the thiophene analogue of Benzedrine, has been developed. The successful condensation of the readily available 2-thenaldehyde and various substituted 2-thenaldehydes (4) with nitromethane and 2-thenaldehyde with nitroethane to form the corresponding nitroolefins, was recently reported (5). These latter compounds have now been satisfactorily reduced to the desired saturated amines.
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