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Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA. 
“Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans”. 
Circulation. 2005 Oct 25;112(17):2642-9.
Sildenafil inhibits phosphodiesterase 5 (PDE5A) to elevate intracellular cGMP and to induce vasodilation. This effect has led to its use for treating erectile dysfunction. Although its influence on rest heart function has appeared minimal, recent animal studies suggest that sildenafil can have potent effects on hearts stimulated by beta-adrenergic or pressure overloads. We therefore tested whether sildenafil blunts dobutamine-stimulated cardiac function in humans.
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