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Park WK, Azmitia EC. 
“5-HT, MDMA (ecstasy), and nimodipine effects on 45Ca-uptake into rat brain synaptosomes”. 
Ann N Y Acad Sci. 1991;635:438-40.
Ca24 entry into cells is one of the initial steps in cell death. MDMA-induced neuropathology of cultured serotonergic neurons is linked to 5-HT release and attenuated by nimodipine. Rat brain synaptosomes were used as an in vitro system to measure 45Ca24 entry. To test the possible mechanism of MDMA-induced stimulation of Ca entry and thc role of thc 5-HT system on regulating brain Ca24 channels, wc modified an in vitro microassay system for use with 96-well plates (NUNC. Denmark).
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