Erowid.org: Erowid Reference 860 : Diminished corticotropin and enhanced prolactin responses to 8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated rats : Poland RE

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Poland RE. “Diminished corticotropin and enhanced prolactin responses to 8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated rats”. Neuropharmacology. 1990;29(11):1099-101. <a name="ref">Poland RE.</a> <a href="/references/860">"Diminished corticotropin and enhanced prolactin responses to 8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated rats"</a> <i>Neuropharmacology</i>. 1990;29(11):1099-101.
Text Abstract (this page) Full Text - English (private) Show Articles by Poland RE Article IDs Erowid RefID: 860 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Although (+/-) methylenedioxymethamphetamine (MDMA) has been reported to deplete serotonin (5-HT) and destroy 5-HT terminals in the brains of animals, the functional sequelae of such alterations remain to be established. In the present study, a blunted corticotropin and an enhanced prolactin response to the 5-HT1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH DPAT) was found in rats treated two weeks previously with a single dose of MDMA (2.0 or 20.0 mg/kg, sc). These results suggest that neurochemical changes produced by MDMA are associated with functional alterations as manifested by abnormal 5-HT receptor-coupled neuroendocrine responses.
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