Erowid.org: Erowid Reference 878 : Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration : Ricaurte GA, DeLanney LE, Irwin I, Langston JW

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Ricaurte GA, DeLanney LE, Irwin I, Langston JW. “Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration”. Brain Res. 1988;446(1):165-8. <a name="ref">Ricaurte GA, DeLanney LE, Irwin I, Langston JW.</a> <a href="/references/878">"Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration"</a> <i>Brain Res</i>. 1988;446(1):165-8.
Text Abstract (this page) Full Text - English (private) Show Articles by Ricaurte GA DeLanney LE Irwin I Langston JW Article IDs Erowid RefID: 878 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract This study compared the toxic effects of oral versus subcutaneous and single versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in non-human primates. Orally administered MDMA was approximately one-half as effective as subcutaneously administered drug. Multiple doses were more effective than single doses, but a single 5 mg/kg dose of MDMA given orally still produced a long-lasting depletion of serotonin in the monkey brain. These results indicate that when MDMA is given to monkeys in a manner similar to that employed by humans, it exerts toxic effects on central serotonergic neurons. This suggests that humans using MDMA may be at risk for incurring central serotonergic neuronal damage.
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