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Anand JS, Glebocka ML, Korolkiewicz RP. 
“Recreational abuse with benzydamine hydrochloride (tantum rosa)”. 
Clin Toxicol (Phila). 2007;45(2):198-9.
Use of illicit and atypical drugs by young people is a burgeoning cultural trend. Such recreational drug use is associated with several medical complications, both acute and long lasting (1). We describe a case involving a 22-year-old man with a history of cannabinoid and alcohol use who was admitted to the clinic after ingesting 500 mg of benzydamine hydrochloride (Tantum Rosa, a sachet for vaginal douche, 500 mg). About two hours before admission he drank one sachet of Tantum Rosa (500 mg of benzydamine for vaginal application) dissolved in about 250 ml of water. At the time of admission the patient was conscious but disoriented. His blood pressure was 120/70 mmHg, heart rate was 96 beats/minute, and respiratory rate was 18 breaths/minute. His evaluation revealed hyperreactivity, excitation, visual hallucinations, and muscle weakness (especially of the lower limbs). Serum electrolytes, glucose, creatinine, creatine phosphokinase, bilirubin, complete blood count, arterial blood gases, and hepatic transaminases were within the normal ranges. Toxicological analysis found no alcohol, amphetamines, opiates, or cannabinoids. Treatment was symptomatic and supportive. The hallucinations, excitation, and hyper-reactivity lasted for about 10 hours; muscle weakness resolved after 48 hours of hospitalization.
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