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Ltd Ed 'Solve et Elucido' Art Giclee
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Mescaline Dosage
by Erowid

Oral Mescaline HCl Dosages
Threshold100 mg
Light100 - 200 mg
Common200 - 300 mg
Strong300 - 500 mg
Heavy500 - 700 mg

Onset : 45 - 60 minutes
Peak : T + 4 hours
Duration : 4 - 8 hours
Normal After Effects : 2 - 4 hours

If an acid extraction is performed on mescaline containing plant material, different forms of mescaline are produced, depending on the acid used. If hydrochloric acid is used the result is mescaline hydrochloride. If sulphuric acid is used, the result is mescaline sulfate. If citric acid is used, the result is mescaline citrate. And if acetic acid (vinegar) is used, the result is mescaline acetate. Each of these forms has a different molecular weight and therefore well as having a different level of solubility in water (the more soluble it is in water, the more mescaline will be extracted from the plant material in an aqueous extraction).

The two most commonly produced synthetic forms of mescaline are mescaline hydrochloride and mescaline sulfate which have very similar dosages. Mescaline sulfate is 11% heavier than mescaline hydrochloride, meaning it takes 11% _more_ mescaline sulfate by weight to get the same effects as a certain amount of mescaline hydrochloride.

If an acid--base--solvent extraction is done on the plant material the result is freebase mescaline. Freebase mescaline is 15% lighter than mescaline hydrochloride (and 25% lighter than mescaline sulfate), thereby requiring 15% _less_ material by weight for the same dose as mescaline hydrochloride. However, most (if not all) extractions end with the freebase being turned into a salt. If the extracted mescaline is not converted to a salt and the solvent is evaporated, it can readily form a salt with the carbon dioxide in the air, forming Mescaline carbonate (molecular weight unknown?).

More information about calculating mescaline dosages

Mescaline is found in many types of cacti, most prominently in peyote (lophophora williamsii), San Pedro (trichocerus pachanoi) and the Peruvian Torch (trichocerus peruvianus). The mescaline content of the various mescaline containing cacti varies greatly between individual samples as well as between species. Following is an estimate of the mescaline contents of these three species. Although there has long been a myth that Trichocerus peruvianus is "10 times" stronger than T. pachanoi, there is not much data to support this view. Many reports indicate that peruvianus may be somewhat stronger than pachanoi, but this is hotly disputed among cactus experts. See A Look at the Mescaline Content of T. peruvianus and T. pachanoi.
  • Lophophora williamsii - 300 mg / 27 g dried material
  • Trichocerus peruvianus - 300 mg / 15 to 100 grams dried material (.3% - 2.0%)
  • Trichocerus pachanoi - 300 mg / 15 to 100 grams grams dried material (.3% - 2.0%)

178 mg mescaline HCl = 200 mg mescaline sulfate.

Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.

Erowid's dosage information is a summary of data gathered from users, research, and other
resources and should not be construed as recommendations. Individuals can respond
differently to the same dosage. What is safe for one can be deadly for another.

Start low with new substances.
Have trusted companion/guide/sitter/friend present and/or available.