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Unexpected X-Tolerance
6-APB, MDMA & Mushrooms - P. cubensis
by SacralChakra
Citation:   SacralChakra. "Unexpected X-Tolerance: An Experience with 6-APB, MDMA & Mushrooms - P. cubensis (exp115827)". Oct 16, 2021.

T+ 0:00
70 mg oral 6-APB (powder / crystals)
  T+ 5:00 70 mg oral MDMA (powder / crystals)
  T+ 7:00 7 g oral Mushrooms - P. cubensis (dried)
  T+ 24:00   oral Vitamins / Supplements  
  T+ 24:00   oral Tryptophan - L-Tryptophan  
  T+ 96:00 0.5 g oral Mushrooms - P. cubensis (dried)


The cross-tolerance between 6-APB and psychedelics is very little documented, so I'd like to detail my experience here. I (Male, 38y, 81kg) am well experienced in psychonautics, my primary focus is trauma healing and spiritual development. I have experimented with flipping, i.e. combining a stimulant (MDMA, 6-APB) and a psychedelic (shrooms, 2C-B, mescaline, LSD) in different orders of intake and a time between them (up to 4 hours). In this report, the time between was more than four hours, and therefore the outcome surprised me, I think.

My last trip before this experience was 2 months ago. I intended to take 6-APB and flip it with a large dose of shrooms.

Time+0h: I take 70mg 6-APB (HCl salt) from a trusted source. It's 5 pm and I have had a beautiful day, feeling fulfilled. My intention for this voyage is sexual healing and spirituality (quest for wholeness).

Time+1h: The effects creep in. I turn on music from a playlist that I had carefully prepared before. I feel goodness in my body, electricity in my skin. Emotionally I am starting to feel psychedelic effects of "opening up". In my experience, this distinguishes 6-APB from MDMA, the latter opens the heart.

Time+2h: Still coming up. Psychedelic effects are stronger - emotions arise, wanting to be seen and felt. I get a strong diarrhea, have to shit a couple of times. Shitting prevents me from doing yoga. I start to dance on some music, shake and pulse.

Time+3h: I'm peaking. Sexual feelings are very strong (desire, pleasure in the pelvis). At this point, I feel that psychedelic effects are being replaced by euphoria.

Time+5h: I feel I'm missing a bit more. I drop 70 mg of MDMA as a booster dose. (I don't have good experiences with redosing 6-APB. It gets way too stimulating.
I don't have good experiences with redosing 6-APB. It gets way too stimulating.

Time+6h: I feel strong effects of the two substances. I am listening to guided meditations and experience profound realizations for my personal life. The MDMA definitely potentiated the roll.

Time+7h: I remember my original intention to flip with shrooms. I weigh 7g of dried psilocybe cubensis in powder. I shake the container with the powder well. This is a large dose (normally), but I know that the shrooms are approximately at half of the maximal potency. A bit of shrooms is still left in the container.

Time+8h: Not much is going on, the stimulants are wearing off. I feel sleepy.

Time+9h: I have no visuals, no change in the perception of music, no emotional effects. Listening to music, I fall asleep.

Time+10h: I wake up, surprised, that I haven't had any effects from the shrooms. Still feeling like I'm coming down slowly from the 6-APB, but there is no violent "crash", no depression.

Time+11h: I decide to close the voyage. I am grateful for the 6-APB roll and I conclude that the shrooms must have had lost their potency completely (in a few days I disprove this statement). I take a warm bath, eat some fruits, drink a sip of red wine. I fall asleep in two-three hours.

Time+1d: On the next day I wake up with 5-6 hours of sleep. I feel an afterglow, mainly due to realizations and lessons from the 6-APB. I am tired, but I don't have a hangover -- there are no adverse effects in the body or brain. It makes me feel that 6-APB is gentler to my neurons than a full-blown MDMA roll. For a couple of days I take vitamins and L-tryptophan. I don't have any depression, which normally comes after full MDMA roll for me.

Time+4days: In the morning, I open the container with dried shrooms, the same that I had used a couple of days ago. I found that there are only 0.5 grams left. I decide to take them as a microdose, not expecting anything to happen. But within one hour (at work) I start to feel the familiar visual, auditory and emotional effects of the shrooms. The music on the radio attracts my attention suddenly. I keep working and have no problems to concentrate on the work. This is definitely not a trip, but it qualifies as a microdose. I am more in touch with my emotions through the day.

Conclusion: I think that the reason I did not feel any effects from the 7g shrooms is that a tolerance had built. I speculate that the 6-APB was the reason, because it's more psychedelic than MDMA. Although an interaction between 6-APB and MDMA can not be excluded. I found no information in the fora about the cross-tolerance between 6-APB and psychedelics. I only found somebody reporting it for MDA. Anecdotally, MDA is quite similar to 6-APB, being a bit psychedelic. I thought that this receptor experiment would be worth submitting here.

A final thought: I think that the cross-tolerance needs several hours to develop. The time between 6-APB and shrooms was 7 hours. This is much longer than I would do usually for flipping (4 hours). When I flipped with 4 hours in the past, my expectations were fulfilled.

Exp Year: 2021ExpID: 115827
Gender: Male 
Age at time of experience: 38 
Published: Oct 16, 2021Views: 573
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6-APB (516), MDMA (3), Mushrooms - P. cubensis (66) : Therapeutic Intent or Outcome (49), Combinations (3), Small Group (2-9) (17)

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