Citation: Tryptamine Fiend. "Positive, Sought-After Effects Were Diminished: An Experience with Mushrooms & Paroxetine / LSD & Paroxetine (exp79225)". Erowid.org. Mar 1, 2021. erowid.org/exp/79225
Paroxetine and Tryptamine
I've noticed a lot of people are wondering about the interactions between SSRI's and hallucinogens. I've been taking Paxil (Paroxetine) at a dosage of 20mg a day for about 2 years. Before I started using Paxil I was a daily Cannabis user and consumed hallucinogens like Shrooms and Acid on the weekends. I thought they the absolute best drugs ever. They were very cheap and produced LOTS of laughter, visual and auditory hallucinations. It was very enjoyable. After I began the Paxil I found that the psychedelics had lost their magic for me.
After I began the Paxil I found that the psychedelics had lost their magic for me.
One time I ingested 2 hits of Blotter LSD. It kicked in after about half an hour but I just wasn't the same anymore. The body feeling felt the same as it used to but the hallucinations were diminished as well as the euphoria. It just wasn't as fun.
Another time in the fall of 2008, shroom season was upon me again. I live in Newfoundland, Canada and Psilocybe Similanceata (Liberty Caps) grow in abundance late in the fall. I picked a shit load of 'em and boiled myself a cup of shroom tea. Typically, I use about 50 decent size undried, fresh mushrooms per cup of tea. This used to get me real fucked up before the Paxil but this time around I just couldn't get to where I wanted to be. I felt the body feeling and felt more emotional but that's it. No hysterical laughter, hardly any entertaining hallucinations...it was just dull. I drank 2 more cups of potent tea but it just wasn't working for me. It seems the neutral or negative effects were present but the positive, sought-after effects were seriously diminished. Of course this may not be the same for everyone.
The point of this report is that, for me, Paroxetine has had a negative effect on how I experience LSD and Psilocybin. Its seems to have no effect on Marijuana except that I don't laugh as much on it, but that may just be because I smoke it so often.
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