Citation: Murple. "Combining Ecstasy with Syrian Rue: An Experience with Ecstasy (MDMA) & Syrian Rue (exp8184)". Erowid.org. Jul 17, 2001. erowid.org/exp/8184
I've mixed MDMA and syrian rue before on several occasions, taking the rue either before or at the same time as the MDMA. I have also mixed Syrian rue with another phenethylamine, mescaline.
Neither caused any problems at all (although when I mixed it with mescaline, I did end up puking, but that happens to me with rue most times anyway, and the mescaline+rue puking was much milder than any tryptamine+rue combination has ever caused). In the case of mixing it with MDMA, it was quite enjoyable and something I will undoubtedly do again. It produces a pretty strong potentiation and adds a new (and quite profound) earthy spiritual dimension to the experience.
The one caution is to use low doses of MDMA. In high enough doses, MDMA itself can kill - as can most amphetamine derivatives. Taking MDMA with an MAOI will lower the overdose threshhold since you are potentiating its effects. If you choose to mix MDMA with Syrian rue, start with no more than half your usual dose of MDMA.
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