Do you think you might have HPPD?
Take this survey out of University of East London,
which attempts to understand the inner experiences of
people with lasting perceptual changes from use of
psychoactive drugs, (diagnosed or not). It investigates
factors that could create distress or effect quality of life.
Stoned Longer Than Wanted
Mushrooms - P. mexicana, Cannabis, Venlafaxine & Mirtazapine
by st51
Citation:   st51. "Stoned Longer Than Wanted: An Experience with Mushrooms - P. mexicana, Cannabis, Venlafaxine & Mirtazapine (exp99225)". Aug 15, 2019.

T+ 0:00
30 mg oral Pharms - Mirtazapine (daily)
  T+ 0:00 150 mg oral Pharms - Venlafaxine (daily)
  T+ 0:00 5 g oral Mushrooms - P. mexicana  
  T+ 0:50 5 g oral Mushrooms - P. mexicana  
  T+ 3:00   smoked Cannabis  


Decided to try psilocybin for the first time and got 10 g of p. mexicana spores. The trip was very mellow, pleasurable, and intensified the positive effects of cannabis. The negative surprise was that cognitive aftereffects persisted for up to to T+10 (!) days
cognitive aftereffects persisted for up to to T+10 (!) days
. Probably both the mild trip and the long aftereffects were due to interactions with SSRI/SNRI medications. Possibly some kind of neurotransmitter response to the psilocybin?

Set and setting: alone, in calm hotel room with 48 hours to spare, prepared peaceful environment with meditation and music. (and pen and paper for notes)

Day 1

T: ate 5 g of p. mexicana spores
T+ 15 mins: slight dizziness
T+ 20 mins: mind drifting, free association changed.
T+ 45 mins: daydreaming, music background sounds wider
T + 50 mins: ate remaining 5 g of mushrooms
T + 1h40: short-term memory lapses
T + 1h55: watching comedy shows--they seem much more fun than usual
T + 3h: significantly milder effects than I expected. No hallucinations, effects seem very similar to medium-strength cannabis. Decide to go out and smoke a joint.
T + 5 h: go to vegetarian dinner--food tastes very good. Feeling quite stoned but able to interact normally with people.
T + 7 h: smoke second joint. Spacing out, time dilation, intensified senses. Fast free association, feeling very good. Memory lapses. Lateral thinking. Write note to self: 'The delusion is that all of our normal life matters and is important:'
T + 8 h: decide to have second dinner.

Day 2

Feeling completely free of anxiety and philosophical. Smoke strong joint. This sends me into a very spiritual mode. Deep derealization. Thinking that all of the life on the surface of this ball of rock is just bubbling mud reaching out for sunlight.
Feel like I see and feel mu (a zen koan thing) in 3D. Thinking: this is it. There's mu. This is enlightenment. None of this matters, and it's all quite funny really: We live on a ball suspended in emptiness.

Couple of hours after that: less clear, more foggy mind. Afternoon is pleasurable but hazy. Music, food, humor, sex seem much intensified. Smoke joint in the evening.

Day 3

Last strong joint at around noon (it's Sunday). More body high, less philosophical than day before. Very relaxed.

Day 4

Monday morning. Negative surprise: I still feel quite stoned. This has never happened on cannabis only. Memory lapses, extreme difficulty concentrating. Certainly cannot drive or operate machinery. Feeling very weird and anxious at work. Feel it must be obvious that I am in an altered state. Yet none of the people I interact with, who know me very well, seem to notice anything. Ego boundaries very weak: anything people say affects me much to an almost unbearable extent.

Days 5-7

Quite similar to day 4. Almost no change. Clearly altered state to me, nobody else seems to notice anything, concentration very poor, senses heightened. Not a displeasurable state at all. Very mellow and relaxed, medium stoned. If could just relax and be by myself no problem at all. But work and other responsibilities causing anxiety. Also, occasionally worried is this permanent? Researching serotonin receptors and wondering if long-term effect is due to SSRI/SNRI medication. The psilocybin and THC must be long clear of my system, so probably must be an endogenous neurotransmitter response to the psilocybin shock. Wondering how long this is going to last. On day 6, halve the mirtazapine to 15 mg just in case this is excess serotonin.

Day 8

In the evening, finally starting to feel normal! Relieved--it's not permanent.
In the evening, finally starting to feel normal! Relieved--it's not permanent.
Then remember that normal is not that pleasant, anxious and depressed. The long altered state was good by itself, just anxiety-provoking in combination with day-to-day responsibilities.

Days 9-10

Feeling almost normal. Still slight loss of concentration and heightened senses.


Psilocybin with SSRIs/SNRIs caused a relatively mild altered state with no hallucinations. Cannabis effects were clearly intensified, with strong spiritual states that persist in normal modes of consciousness. Experienced significant anxiety when stoned sensation continued for almost a week. Will not try psilocybin again at least while on antidepressants due to unpredictable long-term response. For me, just cannabis seems to have a more predictable and time-contained effect.

Exp Year: 2013ExpID: 99225
Gender: Male 
Age at time of experience: 40 
Published: Aug 15, 2019Views: 1,028
[ View as PDF (for printing) ] [ View as LaTeX (for geeks) ] [ Switch Colors ]
Mushrooms - P. mexicana (193) : Hangover / Days After (46), Combinations (3), Alone (16)

COPYRIGHTS: All reports are copyright Erowid.
TERMS OF USE: By accessing this page, you agree not to download or analyze the report data without contacting Erowid Center and receiving written permission prior to your downloading the data.

Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.

Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults