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Ayahuasca: alkaloids, plants & analogs
assembled by Keeper of the Trout
Section 3 : Part 2 :
Jurema : Pharmacological Evaluations

Mimosa tenuifolia stem bark possesses significant in vitro nonspecific growth inhibition of all fungi and gram negative and gram positive bacteria it was tested against. It also suppressed the growth of yeasts but was the least effective against Candida albicans. The activity was most pronounced in the tannin-rich ethyl acetate extracts.

The total alkaloid fraction from the trunk bark, most concentrated in the butanolic extract, was found (in vitro) to inhibit the peristaltic reflex in isolated guinea-pig ileum; and produced contractions of gastric and uterine strips taken from rats and guinea-pigs.

There were saponins present in both butanolic and methanolic extracts that were capable of hemolysis.

diversity of bioactive compounds" was found to be present in the stembark.

Conflicting results in the modification of W138 and KB cells' growth rates in vitro.

All pharmacological evaluations, other than Gonçalves de Lima, looked only at the stem-bark.


Suggested reading:

Gonçalves de Lima 1946 Arquivos do Instituto Pesquisas Agronomicas 4: 45-80.

Loyoza et al. 1989 Archivos de Investigación Médica (México) 20 (1): 87-93.

Meckes-Lozoya et al. 1990 Archivos de Investigación Médica (México) 21 (2): 171-174.

Meckes-Lozoya et al. 1991 Archivos de Investigación Médica (México) 21 (2): 163-169.

Villarreal et al. 1991 Archivos de Investigación Médica (México) 22 (2): 163-169.