Erowid References Database
“Serotonin, psilocybin, and body dysmorphic disorder: a case report.
J Clin Psychopharmacology. 1996 Apr;16(2):188-9.
Body dysmorphic disorder, preoccupation with an imagined defect in appearance, or excessive concern with a slight physical anomaly, has been successfully treated recently with serotonin reuptake inhibitor (SSRI) medication [1,2], which has led to the proposition of a possible serotonergic basis for this disorder [1,2]. Further evidence of this theory comes from reports of exacerbation of body dysmorphic disorder during tryptophan depletion  and use of the 5-HT antagonist cyproheptadine . In support of this theory we present a case in which body dysmorphic symptoms were qualitatively altered with the ingestion of psilocybin, a potent serotonergic agent  in a patient who later responded to the SSRI fluoxetine.
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