Erowid.org: Erowid Reference 1575 : Serotonin and norepinephrine as antagonistic chemical mediators regulating the central autonomic nervous system. (Neuropharmacology. Transactions of the 3rd Conference, May 21-23, 1956, Princeton, NJ, Ed. by HA Abramson) : Brodie BB

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Brodie BB. “Serotonin and norepinephrine as antagonistic chemical mediators regulating the central autonomic nervous system. (Neuropharmacology. Transactions of the 3rd Conference, May 21-23, 1956, Princeton, NJ, Ed. by HA Abramson)”. Josiah Macy Foundation. 1957;p323. <a name="ref">Brodie BB.</a> <a href="/references/1575">"Serotonin and norepinephrine as antagonistic chemical mediators regulating the central autonomic nervous system. (Neuropharmacology. Transactions of the 3rd Conference, May 21-23, 1956, Princeton, NJ, Ed. by HA Abramson)"</a> <i>Josiah Macy Foundation</i>. 1957;p323.
Texts Abstract (this page) Full Text - Multiple (153 K) Full Text - English (1002 K) Show Articles by Brodie BB Article IDs LSDID: 0426 Erowid RefID: 1575 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Studies on 5-hydroxytryptamine, reserpine, chlorpromazine, LSD, iproniazid and monoamine oxidase led to a working hypothesis that 5-hydroxytryptamine and norepinephrine are antagonistic chemical mediators regulating the central autonomic nervous system. The findings include the following: . Monoamine oxidase inactivates 5-hydroxytryptamine in vitro. This inactivation is blocked by oproniazid and, to almost the same extent, by LSD. . LSD blocks reserpine-induced potentiation of hypnotics but not chlorpromazine-induced potentiation of hypnotics. . Reserpine stimulates the parasympathetic system by releasing 5-hydroxytryptamine. LSD produces sympathetic stimulation by blocking 5-hydroxytryptamine. Chlorpromazine inhibits the sympathetic system by blocking norepinephrine.
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