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Reed LJ, Winstock A, Cleare AJ, McGuire P. 
“Toxic effect of MDMA on brain serotonin neurons”. 
Lancet. 1999 Apr 10;353(9160):1268; discussion 127.
The large range in [11C]-McN-5652 binding among controls and the observation that most of the MDMA users fell within this range, questions the sensitivity and specificity of the technique. Furthermore, the investigators describe a negative correlation between cumulative MDMA dose and [11C]-McN-5652 binding, but this correlation was evident only when the controls were included in the analysis: no relation is discernible when the MDMA users are considered.
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