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Burt DR, Creese I, Snyder SH. 
“Binding Interactions of Lysergic Acid Diethylamide and Related Agents with Dopamine Receptors in the Brain”. 
Mol.Pharmacol.. 1976;12(4):631-38.
Binding interactions of LSD and related agents with dopamine receptors in the brain are described. In calf hippocampus and caudate binding of (3H) LSD involved the postsynaptic serotonin receptors but in the latter about 330f the binding involved the postsynaptic dopamine receptors. In the hippocampus, dopamine competed for (3H) LSD binding sites with a single low affinity and in the caudate it displayed high and low affinity components, the former accounting for 15-20% (3H) LSD binding. Addition of serotonin (Aegis) increased the proportion of (3H) LSD binding competed for by dopamine with high affinity. d-LSD and several ergot alkaloids (ergotamine, ergocornine, ergocristine, ergometrine, cr-ergocryptine, CB 154 (Sandoz)) showed high affinity for (3H) dopamine receptor binding in the caudate, so that the drugs cannot be considered 'pure' serotonin agonists or antagonists, Values for 50 0nhibition of (3H) dopamine binding are tabulated, Drugs tested were methiothepin (Roche), methysergide, cyproheptadine (SK+F), mianserin (Organon), tryptamine, 5-methoxytryptamine, bufotenine, psilocin and N,Ndimethyltryptamine (all Regis), mescaline, psilocybin, R(-)-, S(+)- and (-)-Z,5-dimethoxy-4-ethylamphetamine and -methylamphetamine (Barfknecht), apomorphire (Merck), (+) butacIamoI (Ayers"), dopamine (Sigma) and fluphenazine (Squibb).
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