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Laurent JP, Pieri L. 
“Lisuride and LSD decrease Spontaneous firing of neurons in the raphe”. 
Experientia. 1978;34(7):926.
Multiunit activity was recorded from the raphe dorsalis by means of plantinum-iridium wires (50 mcm in diameter) in curarized rats. Impulses, sifted through a window discriminator, were counted every 4 min for statistical evaluation (t-test). Lisuride maleate (10 mcg/kg i.v.) induces a 50 0ecrease (4 rats P < 0.001) and recovery is almost complete 1 hr later. In the pontine reticular formation, no major modification occurs (3 animals) with the same dosage. LSD bitartrate (10 mcg/kg i.v.) induces a 20 0ecrease (5 rats 1 mcg 0.001 of the multianit activity; 1 hr thereafter, the baseline level has not yet been reached. The effect of lisuride has been qualitatively confirmed by single unit analysis of neurons in the raphe medialis under urethane anesthesia. In conclusion, lisuride, a structural analog of LSD, is 2-3 x more potent than LSD in decreasing firing of raphe neurons. These results are in accordance with the hypothesis that lisuride can in part act through serotoninergic receptors on raphe neurons. On the other hand, it should be emphasized that, despite its greater potency than LSD on raphe neurons, lisuride exhibits no hallucinogenic effects in man.
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