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Takeda K, Ando K, Yanagita T. 
“Operant behavioral observation on visual and auditory effects of drugs”. 
Jap.J.Pharmacol.. 1976;26(Suppl.):105P.
Rats and rhesus monkeys were trained to press a lever for food reinforcement, Lever pressing during auditory and visual stimulus periods was punished by electric shock. Complete suppression of responses in the stimulus period and stable responses in the stimulus-free period were observed. The auditory threshold of rats and the visual threshold of monkeys were determined by discrete tracking; stimulus intensity was decreased or increased by a fixed degree, step by step, according to the suppression rate of the responses in the stimulus period. Quinidine at 20 mg/kg i.m. elevated the auditory threshold of rats while the response suppression in the visual stimulus period and the responding rate in the stimulus-free period were not affected. LSD-25 at doses of 4 and 8 mcg/kg, s.c. markedly elevate the visual threshold of 1 monkey, however, the threshold of another monkey was not affected at 20 mcg/kg although the rate of response decreased. Pilocarpine applied to a monkey's eyeball in a dose of 0.02-0.16 mg/kg/eye constricted the pupil and elevated the visual threshold. It was concluded that the drugs tested had specific effects on the sensory functions of the animals, and that this method can be use for assessing the toxic effects of chemical substances on auditory and visual sensations.
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