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Schachter M, Godfrey PP, Minchin MCW, McClue SJ, Young MM. 
“Serotonergic Agonists Stimulate Inositol Lipid Metabolism In Rabbit Platelets”. 
Life Sciences. 1985;37(17):1641-1647.
The metabolism of inositol phospholipids in response to serotonergic agonists was investigated in rabbit platelets. In platelets prelabelled with[3H]-inositol in a medium containing 10 mM LiCl which blocks the enzyme inositol-1-phosphatase, 5-hydroxytryptamine(5-HT)caused a dose-dependent-accumulation of inositol phosphates(IP) This suggests a phospholipase-C-mediated breakdown of phosphoinositides. Ketanserin, a selective 5-HT antagonist, was a potent inhibitor of the 5-HT response, with a Ki of 28-nM, indicating that 5-HT is activating receptors of the 5-HT type in the platelet. Lysergic acid diethylamide (LSD) and quipazine also caused dose-related increases in inositol phosphate-levels, though these were considerably less than those-produced by 5-HT. These results show that relatively small changes in phosphoinositide metabolism induced by serotonergic agonists can be investigated in the rabbit platelet, and this cell may therefore be a useful model for the study of some 5-HT receptors.
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