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Luscombe G, Jenner P, Marsden CD.
“Correlation Of [3h]5-hydroxytryptamine (5ht) Binding To Brain Stem Preparations And The Production And Prevention Of Myoclonus In Guinea Pig By 5ht Agonists And Antagonists”.
European Journal of Pharmacology Is. 1984;104:235-244.
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Abstract
In guinea pig brain stem preparations [3H]5-hydroxytryptamine (5HT) bound specifically to both high and low affinity sites, but specific [3H]spiperone binding was low and could not be consistently detected. This indicates a prevalence of 5HT-1 type receptors inthis tissue. High affinity-specific [3H]5HT binding was more potently displaced by indole-containing 5HT agonists than by piperzine-containing 5HT agonists. This agreed with the observation that indole-containing, but not piperazine containing compounds induced dose-dependent myoclonus in guinea pigs which originates from brain stem. The capacity of indoleamine antagniosts to displace [3H]5HT from 5HT-1 receptors. The [3H]5HT-labelled binding site in guinea pig brain stem is a 5HT-1 receptor and appears to be responsible for the induction of indoleamine-dependent myoclonus.
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