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Mokler DJ, Commissaris RL, Rech RH. 
“Drugs that influence dopamine function do not alter the disruption of operant behavior by lisuride (LIS), lysergic acid diethylamide (LSD) or d-amphetamine (d-A)”. 
Federation Proceedings. 1982;41(4):1072.
Some investigators have indicated that LSD may exert hallucinogenic effects, in part at least, through dopaminergic (D) influences If LSD acts by way of D systems the D antagonists haloperidol (HAL) and chlorpromazine (CPZ) as well as o-methyl-p-tyrosine (o-MT), may be expected to attenuate the LSD disruption of Fixed ratio (FR-40) behavior. We also examined the effects of bAL, CPZ and alpha-MT tan the disruption of FR- 40 behavior by d-A and LIS. LIS is a non-hallucinogenic analog of LSD reported to have activity. Male Sprague Dawley rats were trained to bar-press for food reinforcement on an FR-40 schedule. Drugs were administered i.p. in distilled water after 2-3 days of control responding in 40 min daily sessions, The number of reinforcements and 10-sec pause intervals on a dosing day were compared with the mean of the control days immediately prior. Neither the LSD (25-200 mcg/ kg) nor LIS (10-120 mcg/kg) dose-response curves or pause intervals were shifted by HAL (0.05: mg/kg), CPZ (0.5 mg/kg) or alpha-MT (100 mg/kg). Disruption of FR40 behavior by d-A (0.25-8 mg/kg) was similarly not affected by pretreatment with HAL, CPZ or AMP. Thus, disruption of operant behavior by LIS, LSD or d-A may not involve D mechanisms.
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