Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Fukuto JM, Kumagai Y, Cho AK. 
“Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects”. 
J Med Chem. 1991;34(9):2871-6.
The mechanism of demethylenation of (methylenedioxy)benzene (MDB), (methylenedioxy)amphetamine (MDA), and (methylenedioxy)methamphetamine (MDMA) by purified rabbit liver cytochrome P450IIB4 has been investigated by using deuterium isotope effects. A comparison of the magnitude and direction of the observed kinetic isotope effects indicates that the three compounds are demethylenated by different mechanisms. The different mechanisms of demethylenation have been proposed on the basis of comparisons of the observed biochemical isotope effects with the isotope effects from purely chemical systems.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]