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Caporael LR. 
“Ergotism: the satan loosed in Salem?”. 
Science. 1976 Apr 2;192(4234):21-6.
Numerous hypotheses have been devised to explain the occurrence of the Salem witchcraft trials in 1692, yet a sense of bewilderment and doubt pervades most of the historical perspectives on the subject. The physical afflictions of the accusing girls and the imagery of the testimony, therefore, is dismissed as imaginary in foundation. One avenue of understanding that has yet to be sufficiently explored is that a physiological condition, unrecognized at the time, may have been a factor in the Salem incident. Assuming that the content of the court records is basically an honest account of the deponents' experiences, the evidence suggests that convulsive ergotism, a disorder resulting from the ingestion of grain contaminated with ergot, may have initiated the witchcraft delusion.

Suggestions of physical origins of the afflicted girls' behavior have been dismissed without research into the matter. In looking back, the complexity of the psychological and social factors in the community obscured the potential existence of physical pathology, suffered not only by the afflicted children, but also by a number of other community members. The value of such an explanation, however, is clear. Winfield S. Nevins best reveals the implicit uncertainties of contemporary historians (1: 2, p. 235).

'. . . I must confess to a measure of doubt as to the moving causes in this terrible tragedy. It seems impossible to believe a tithe of the statements which were made at the trials. And yet it is equally difficult to say that nine out of every ten of the men, women, and children who testified upon their oaths, intentionally and wilfully falsified. Nor does it seem possible that they did, or could invent all these marvelous tales, fictions rivaling the imaginative genius of Haggard or Jules Verne.'

The possibility of a physiological condition fitting the known circumstances and events would provide a comprehensible framework for understanding the witchcraft delusion in Salem.
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