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Mills EM, Banks ML, Sprague JE, Finkel T. 
“Pharmacology: uncoupling the agony from ecstasy”. 
Nature. 2003 Nov 27;426(6965):403-4.
The recreational use of amphetamine-type stimulants can produce a marked and sometimes lethal increase in body temperature. Here we show that mice deficient in a mitochondrial protein known as UCP-3 (for \'uncoupling protein-3\') have a diminished thermogenic response to the drug MDMA (3,4-methylenedioxymethamphetamine, nicknamed \'ecstasy\') and so are protected against this dangerously toxic effect. Our findings indicate that UCP-3 is important in MDMA-induced hyperthermia and point to a new therapeutic direction for solving an increasing public-health problem.
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