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Shulgin AT, Shulgin LA, Jacob P. 
“A protocol for the evaluation of new psychoactive drugs in man”. 
Methods Find Exp Clin Pharmacol. 1986 May 18;8(5):313-20.
A protocol is presented that has proven effective in the determination, in man, of the psychotomimetic potency and qualitative nature of action of a new drug. It involves a minimum of animal screening, but relies heavily upon the use of experienced human subjects. This procedure has been successful in the discovery of over 200 novel CNS-active agents.
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