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Bertilsson L, Koslow SH, Costa E. 
“5-Hydroxytryptamine depletion in mesencephalic nuclei of rat brain following a single injection of p-chloroamphetamine”. 
Brain Res. 1975 Jun 11;91(2):348-50.
A single dose of p-chloroamphetamine PCA reduces the content of 5-hydroxytryptamine 5-HT and 5-hydroxyindoleacetic acid, the turnover rate of 5-HT and the activity of tryptophan-5-hydroxylase in rat brain for several months3,5,11,12. It has been suggested that this long lasting deficit is due to a neurotoxic effect, possibly mediated through a not yet identified epoxide or hydroxylamine metabolite of PCA5,12
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