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Daniel X. Freedman. 
“Aspects of the Biochemical Pharmacology of Psychotropic Drugs”. 
Psychedelic Review. 1966;8:33-58.
Only a decade ago psychopharmacology faced the future equipped more with prescient hopes than with substantive findings 1. Drugs were promised as tools to reveal the coding by which neurochemical as well as neurobehavioral sequences were regulated. Endogenous systems related to stress were to be unmasked and their relationship to behavior pathology revealed. Therapeutic drugs were to be discovered which-if they did not specifically reverse behavior disorder-would at the least set into morion compensatory and inhibitory processes. Drugs thereby would directly or indirectly permit a more successful operation of those contingencies normally regulating behavior and keeping it within acceptable bounds.
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