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Kacker IK, Zaheer SH. 
“Potential analgesics, I. Synthesis of substituted 4-quinazolones”. 
J Indian Chem Soc. 1951;28(6):344-346.
Need abstract or full text to summarize. It is suggested in the literature that this is the first paper to document the synthesis of methaqualone.

[From the original] Using the concept of quarternary carbon and tertiary nitrogen in beta-relationship to each other in a molecule, as an optimal and perhaps an essential feature of potent analgesics, seventeen substituted 4-quinazolones have been synthesised as intermediates in the preparation of substituted 4-quinazolinols and their esters for testing their analgesic activity. [...]
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